If you are using an HDMI cable to connect your PC to a monitor or TV, you may encounter an annoying issue: the moment you toggle fullscreen mode on YouTube (Chrome or Edge) , your NVIDIA High Definition Audio completely disappears . Switching playback devices does nothing, and the only workaround seems to be a full system reboot. This issue occurs because toggling fullscreen triggers a GPU display handshake reset (HDMI Handshake loss) or creates a driver conflict with the browser’s hardware acceleration pipeline. Follow the step-by-step guide below. For over 90% of users, completing just Method 1 and Method 2 solves the problem permanently!